Central Giant Cell Granuloma - Highlights
Central giant cell granuloma (CGCG) is a benign osteolytic lesion of the bone, predominantly affecting the jaws. First described by Jaffe in 1953, CGCG was thought to be a reactive response to intra-bony hemorrhage. It was then called “Giant cell reparative granuloma”.
📝Here are some "Highlights" or a high level overview of Central Giant Cell Granuloma
Two important types of cells that play major roles in disease process of central giant cell granuloma (CGCG) are a) spindle shaped stromal cells (SSCs) and b) multinucleate giant cells.
Spindle shaped stromal cells form the proliferative component. These are “osteoblast-like” cells, since they express many osteoblastic proteins.
CGCG prefers the mandible and occurs most frequently in front of the molars, usually the anteriors.
CGCG is known to cross the midline, meaning extending from one quadrant to another (for example – from mandibular left canine --> crosses the midline --> extends up to the mandibular right canine).
Most cases of CGCG are non-aggressive.
Two important cells to note in the stroma (microscopy) --> a) spindle shaped stromal cells (these are just mononuclear cells that are spindle shaped, resemble fibroblasts) and b) multinucleate giant cells.
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