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Is epithelial dysplasia a significant predictor of malignant transformation of OPMDs?
Q: Is epithelial dysplasia a significant predictor of malignant transformation of OPMDs?
A: It sort of "is" and "is not". Before you get confused let me explain.
The microscopic evaluation for the presence of epithelial dysplasia in OPMDs remains the gold standard for the assessment of these lesions. It is believed that OPMDs with epithelial dysplasia have more chances of malignant transformation. Currently available molecular markers have not been proved to be of able predictors of malignant transformation.
However, it has to be remembered that it is not inevitable that a dysplastic lesion will transform into cancer. There is evidence of dysplastic lesions progressing to carcinoma and also OPMDs without evidence of dysplasia progressing to cancer.
🔎You could delve into more questions…
What’s the deal with precancerous lesions, precancerous conditions and oral potentially malignant disorders? I am confused with these terms.
Is Proliferative Verrucous Leukoplakia a distinct entity?
Besides epithelial dysplasia, can the site and clinical appearance of an OPMD like leukoplakia be a predictor of malignant transformation? '
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