Q: Is epithelial dysplasia a significant predictor of malignant transformation of OPMDs? A: It sort of "is" and "is not". Before you get confused let me explain. The microscopic evaluation for the presence of epithelial dysplasia in OPMDs remains the gold standard for the assessment of these lesions. It is believed that OPMDs with epithelial dysplasia have more chances of malignant transformation. Currently available molecular markers have not been proved to be of able predictors of malignant transformation.